Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 GeneticVariation BEFREE • The glioblastoma subgroup was stratified according to MGMT promoter methylation status. 27048531

2017

Entrez Id: 546
Gene Symbol: ATRX
ATRX
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.380 GeneticVariation BEFREE • Significant correlation exists between radiological parameters such as volumetric and ADC values and major genomic profiles such as IDH mutation and ATRX loss status • Radiological parameters such as the ADC value were feasible predictors of glioblastoma patients' prognosis • Imaging features can predict major genomic profiles of the tumours and the prognosis of glioblastoma patients. 29721688

2018

Entrez Id: 3417
Gene Symbol: IDH1
IDH1
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 GeneticVariation BEFREE • Significant correlation exists between radiological parameters such as volumetric and ADC values and major genomic profiles such as IDH mutation and ATRX loss status • Radiological parameters such as the ADC value were feasible predictors of glioblastoma patients' prognosis • Imaging features can predict major genomic profiles of the tumours and the prognosis of glioblastoma patients. 29721688

2018

Entrez Id: 3418
Gene Symbol: IDH2
IDH2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 GeneticVariation BEFREE • Significant correlation exists between radiological parameters such as volumetric and ADC values and major genomic profiles such as IDH mutation and ATRX loss status • Radiological parameters such as the ADC value were feasible predictors of glioblastoma patients' prognosis • Imaging features can predict major genomic profiles of the tumours and the prognosis of glioblastoma patients. 29721688

2018

Entrez Id: 113451
Gene Symbol: AZIN2
AZIN2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.100 Biomarker BEFREE • Significant correlation exists between radiological parameters such as volumetric and ADC values and major genomic profiles such as IDH mutation and ATRX loss status • Radiological parameters such as the ADC value were feasible predictors of glioblastoma patients' prognosis • Imaging features can predict major genomic profiles of the tumours and the prognosis of glioblastoma patients. 29721688

2018

Entrez Id: 339896
Gene Symbol: GADL1
GADL1
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.100 Biomarker BEFREE • Significant correlation exists between radiological parameters such as volumetric and ADC values and major genomic profiles such as IDH mutation and ATRX loss status • Radiological parameters such as the ADC value were feasible predictors of glioblastoma patients' prognosis • Imaging features can predict major genomic profiles of the tumours and the prognosis of glioblastoma patients. 29721688

2018

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 PosttranslationalModification BEFREE • ASL-PWI can aid to predict IDH and MGMT promoter methylation statuses in GBM. 31468161

2020

Entrez Id: 435
Gene Symbol: ASL
ASL
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.060 GeneticVariation BEFREE ASL-PWI performs well (AUC > 0.8) in differentiating PCNSL from GBM. 29619520

2018

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE GBMs with unmethylated MGMT promoter present higher APTw-MRI than methylated GBMs. 29234914

2018

Entrez Id: 2806
Gene Symbol: GOT2
GOT2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.010 Biomarker BEFREE ω-3 and ω-6 Fatty Acids Modulate Conventional and Atypical Protein Kinase C Activities in a Brain Fatty Acid Binding Protein Dependent Manner in Glioblastoma Multiforme. 29642372

2018

Entrez Id: 2114
Gene Symbol: ETS2
ETS2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.020 Biomarker BEFREE ΔNp73/ETS2 complex drives glioblastoma pathogenesis- targeting downstream mediators by rebastinib prolongs survival in preclinical models of glioblastoma. 31763674

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 Biomarker BEFREE ΔEGFR is a potent glioblastoma oncogene which has been studied primarily as a plasma membrane kinase. 23250739

2013

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.500 AlteredExpression BEFREE ΔEGFR cooperated with STAT5b to regulate the Bcl-XL promoter and knockdown of STAT5b suppressed anchorage independent growth, reduced the levels of Bcl-XL and sensitized glioblastoma cells to cisplatin. 22729867

2013

Entrez Id: 998
Gene Symbol: CDC42
CDC42
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.060 Biomarker BEFREE αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. 23283986

2013

Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.100 Biomarker BEFREE αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. 23283986

2013

Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.100 AlteredExpression BEFREE [Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain. 29286123

2018

Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.080 Biomarker BEFREE [Retracted] FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain. 29286123

2018

Entrez Id: 9860
Gene Symbol: LRIG2
LRIG2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.050 Biomarker BEFREE [Corrigendum] LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling. 30942453

2019

Entrez Id: 27087
Gene Symbol: B3GAT1
B3GAT1
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.010 AlteredExpression BEFREE [<sup>177</sup>Lu]DOTA-[Thi⁸,Met(O₂)<sup>11</sup>]SP(1⁻11), [<sup>177</sup>Lu]DOTA-SP(4⁻11) and [<sup>177</sup>Lu]DOTA-[Thi⁸,Met(O₂)<sup>11</sup>]SP(5⁻11) radiobioconjugates bound specifically to NK-1 receptors expressed on glioblastoma cells with affinity in the nanomolar range. 30301182

2018

Entrez Id: 11126
Gene Symbol: CD160
CD160
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.010 AlteredExpression BEFREE [<sup>177</sup>Lu]DOTA-[Thi⁸,Met(O₂)<sup>11</sup>]SP(1⁻11), [<sup>177</sup>Lu]DOTA-SP(4⁻11) and [<sup>177</sup>Lu]DOTA-[Thi⁸,Met(O₂)<sup>11</sup>]SP(5⁻11) radiobioconjugates bound specifically to NK-1 receptors expressed on glioblastoma cells with affinity in the nanomolar range. 30301182

2018

Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.050 Biomarker BEFREE [<sup>177</sup>Lu]DOTA-[Thi⁸,Met(O₂)<sup>11</sup>]SP(1⁻11), [<sup>177</sup>Lu]DOTA-SP(4⁻11) and [<sup>177</sup>Lu]DOTA-[Thi⁸,Met(O₂)<sup>11</sup>]SP(5⁻11) radiobioconjugates bound specifically to NK-1 receptors expressed on glioblastoma cells with affinity in the nanomolar range. 30301182

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE Zymography analysis also revealed that the activities of MMP-2 and MMP-9 of GBM cells were significantly inhibited in response to 100, 200, or 300 μM naringenin treatment. 30431227

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE Zymography analysis also revealed that the activities of MMP-2 and MMP-9 of GBM cells were significantly inhibited in response to 100, 200, or 300 μM naringenin treatment. 30431227

2019

Entrez Id: 23354
Gene Symbol: HAUS5
HAUS5
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.010 AlteredExpression BEFREE ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5. 28596487

2017

Entrez Id: 407042
Gene Symbol: MIR34C
MIR34C
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.020 AlteredExpression BEFREE Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments. 30890698

2019